Updating the sequence based classification of glycosyl hydrolases

05-Dec-2019 03:23 by 8 Comments

Updating the sequence based classification of glycosyl hydrolases

Among the myriad of genes that have been identified in the human gut microbiome, those that encode carbohydrate-active enzymes (CAZymes) are of particular interest, as these enzymes are required to digest most of our complex repertoire of dietary polysaccharides.

The long and complex evolution of this family of enzymes and its broad sequence diversity limits functional prediction.You should be aware you are not editing our local copy of this information.Any changes that you make to the Wikipedia article will not be displayed here until we next download the article from Wikipedia.Over 6400 proteins have assigned EC numbers and 700 proteins have a PDB structure.The classification (i) reflects the structural features of these enzymes better than their sole substrate specificity, (ii) helps to reveal the evolutionary relationships between these enzymes and (iii) provides a convenient framework to understand mechanistic properties.These families are created based on experimentally characterized proteins and are populated by sequences from public databases with significant similarity.

Protein biochemical information is continuously curated based on the available literature and structural information.

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The Wikipedia text that you see displayed here is a download from Wikipedia.

This resource has been available for over 10 years to the scientific community, contributing to information dissemination and providing a transversal nomenclature to glycobiologists.